Research Articles
From Principle to Practice: Anfinsen's Dogma as the Blueprint for Modern De Novo Protein Design
This article explores the foundational principles, computational methodologies, and cutting-edge applications of de novo protein design, firmly rooted in Anfinsen's thermodynamic hypothesis.
AlphaFold2 vs RoseTTAFold: A Comparative Analysis of Accuracy, Methods, and Impact on Drug Discovery
This article provides a comprehensive and up-to-date comparison of AlphaFold2 and RoseTTAFold, the two leading AI systems for protein structure prediction.
AlphaFold2 Protocol Guide: From Prediction to Validation for Drug Discovery Researchers
This comprehensive guide provides researchers, scientists, and drug development professionals with a detailed, step-by-step protocol for AlphaFold2 protein structure prediction.
AlphaFold2 Revolutionizes Enzyme Engineering: From Structure Prediction to Rational Design in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on leveraging AlphaFold2 for enzyme science.
AlphaFold2 Beyond Structure: Revolutionizing Enzyme Function Annotation for Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on utilizing AlphaFold2 for accurate enzyme function annotation.
Revolutionizing Biologics: How AI-Driven Excipient Selection is Transforming Enzyme Formulation Stability
This article provides a comprehensive overview of the paradigm shift towards artificial intelligence (AI) in the selection of excipients for enzyme-based drug formulations.
AI-Driven Enzyme Design: Revolutionizing Catalysis Through Electrostatic Preorganization
This article provides a comprehensive analysis of AI-driven enzyme design, focusing on the pivotal role of electrostatic preorganization in enhancing catalytic efficiency.
Dynamic Control, Maximized Yield: How AI is Revolutionizing Gentamicin C1a Biosynthesis
This article explores the transformative role of AI and machine learning in dynamically regulating the biosynthesis of the critical antibiotic component, gentamicin C1a.
From Sequence to Function: How AI and Machine Learning Are Revolutionizing Enzyme Prediction in Drug Discovery
This article provides a comprehensive review of the latest AI and machine learning models transforming enzyme function prediction, a critical task in drug discovery and metabolic engineering.
Beyond Prediction: Validating De Novo Enzyme Structures with AlphaFold2
This article provides a comprehensive guide for researchers on the critical validation of AlphaFold2 (AF2)-predicted enzyme structures.